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Molecular zip code draws killer T cells straight to brain tumors December 5, 2024 University of California - San Francisco Scientists have developed a 'molecular GPS' to guide immune cells into the brain and kill tumors without harming healthy tissue. Facebook Twitter Pinterest LinkedIN Email Researchers have found a way to program immune cells to attack glioblastoma and treat the inflammation of multiple sclerosis in mice. The technology will soon be tested in a clinical trial for people with glioblastoma. UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without harming healthy tissue. This living cell therapy can navigate through the body to a specific organ, addressing what has been a major limitation of CAR-T cancer therapies until now. The technology worked in mice and the researchers expect it to be tested in a clinical trial next year. The scientists showed how the immune cells could eliminate a deadly brain tumor called glioblastoma and prevent recurrences. They also used the cells to tamp down inflammation in a mouse model of multiple sclerosis. "Living cells, especially immune cells, are adapted to move around the body, sense where they are, and find their targets," said Wendell Lim, PhD, UCSF professor of cellular and molecular pharmacology and co-senior author of the paper, which appears in Science on Dec. 5. Navigating to the source of disease Nearly 300,000 patients are diagnosed with brain cancers each year in the United States, and it is the leading cause of cancer mortality in children. Brain cancers are among the hardest cancers to treat. Surgery and chemotherapy are risky, and drugs can't always get into the brain. To get around these problems, the scientists developed a "molecular GPS" for immune cells that guided them with a "zip code" for the brain and a "street address" for the tumor. They found the ideal molecular zip code in a protein called brevican, which helps to form the jelly-like structure of the brain, and only appears there. For the street address, they used two proteins that are found on most brain cancers. The scientists programmed the immune cells to attack only if they first detected brevican and then detected one or the other of the brain cancer proteins. Once in the bloodstream, they easily navigated to the mouse's brain and eliminated a growing tumor. Immune cells that remained in the bloodstream stayed dormant. This prevented tissues elsewhere in the body that happened to have the same protein "address" from being attacked. One hundred days later, the scientists introduced new tumor cells into the brain, and enough immune cells were left to find and kill them, a good indication that they may be able to prevent any remaining cancer cells from growing back. "The brain-primed CAR-T cells were very, very effective at clearing glioblastoma in our mouse models, the most effective intervention we've seen yet in the lab," said Milos Simic, PhD, the Valhalla Foundation Cell Design Fellow and co-first author of the paper. "It shows just how well the GPS ensured that they would only work in the brain. The same strategy even worked to clear brain metastases of breast cancer." In another experiment, the researchers used the brain GPS system to engineer cells that deliver anti-inflammatory molecules to the brain in a mouse model of multiple sclerosis. The engineered cells reached their target, and the inflammation faded. The scientists hope this approach will soon be ready for patients with other debilitating nervous system diseases. "Glioblastoma is one of the deadliest cancers, and this approach is poised to give patients a fighting chance," said Hideho Okada, MD, UCSF oncologist and co-senior author of the paper. "Between cancer, brain metastases, immune disease and neurodegeneration, millions of patients could someday benefit from targeted brain therapies like the one we've developed." Story Source: Materials provided by University of California - San Francisco . Original written by Levi Gadye. Note: Content may be edited for style and length. Journal Reference : Cite This Page :

New Video Emerges of UnitedHealthcare CEO’s Suspected KillerColts need help for playoff shot, while Giants seek end to record skid

CLAYTON, Mo. , Dec. 9, 2024 /PRNewswire/ -- As previously announced, Olin Corporation (NYSE: OLN ) will host an Investor Day on Thursday, December 12 from 9:00am – 12:00pm (ET). Ken Lane , President & CEO, and Todd Slater , SVP & CFO, will be joined by other members of the Executive Leadership Team to present an in-depth overview of Olin's strategic vision, including its value-first commercial approach, deep dives into each business, disciplined capital allocation strategy, and updated financial targets. The event will also include an opportunity for in-person and virtual attendees to ask questions during a Q&A session. In person attendance is limited to pre-registered attendees only, however, a live webcast of the event as well as the supporting materials will be available via Olin's website. See below for details. Webcast Details A live webcast will be accessible from www.olin.com . A replay of the 2024 Investor Day will be available within 24 hours of the event's conclusion. Presentation Slides Presentation slides will be available at the time of the event and may be accessed via the Investor Events page on the Olin website. COMPANY DESCRIPTION Olin Corporation is a leading vertically integrated global manufacturer and distributor of chemical products and a leading U.S. manufacturer of ammunition. The chemical products produced include chlorine and caustic soda, vinyls, epoxies, chlorinated organics, bleach, hydrogen, and hydrochloric acid. Winchester's principal manufacturing facilities produce and distribute sporting ammunition, law enforcement ammunition, reloading components, small caliber military ammunition and components, industrial cartridges, and clay targets. Visit www.olin.com for more information on Olin. FORWARD-LOOKING STATEMENTS This communication includes forward-looking statements. These statements relate to analyses and other information that are based on management's beliefs, certain assumptions made by management, forecasts of future results, and current expectations, estimates and projections about the markets and economy in which we and our various segments operate. The statements contained in this communication that are not statements of historical fact may include forward-looking statements that involve a number of risks and uncertainties. We have used the words "anticipate," "intend," "may," "expect," "believe," "should," "plan," "outlook," "project," "estimate," "forecast," "optimistic," "target," and variations of such words and similar expressions in this communication to identify such forward-looking statements. These forward-looking statements include, but are not limited to, statements regarding the Company's intent to repurchase, from time to time, the Company's common stock. These statements are not guarantees of future performance and involve certain risks, uncertainties, and assumptions, which are difficult to predict and many of which are beyond our control. Therefore, actual outcomes and results may differ materially from those matters expressed or implied in such forward-looking statements. We undertake no obligation to update publicly any forward-looking statements, whether as a result of future events, new information or otherwise. The payment of cash dividends is subject to the discretion of our board of directors and will be determined in light of then-current conditions, including our earnings, our operations, our financial conditions, our capital requirements and other factors deemed relevant by our board of directors. In the future, our board of directors may change our dividend policy, including the frequency or amount of any dividend, in light of then-existing conditions. The risks, uncertainties and assumptions involved in our forward-looking statements, many of which are discussed in more detail in our filings with the SEC, including without limitation the "Risk Factors" section of our Annual Report on Form 10-K for the year ended December 31, 2023 , and our Quarterly Reports on Form 10-Q and other reports furnished or filed with the SEC, include, but are not limited to, the following: Business, Industry and Operational Risks sensitivity to economic, business and market conditions in the United States and overseas, including economic instability or a downturn in the sectors served by us; declines in average selling prices for our products and the supply/demand balance for our products, including the impact of excess industry capacity or an imbalance in demand for our chlor alkali products; unsuccessful execution of our strategic operating model, which prioritizes Electrochemical Unit (ECU) margins over sales volumes; failure to identify, attract, develop, retain and motivate qualified employees throughout the organization and ability to manage executive officer and other key senior management transitions; failure to control costs and inflation impacts or failure to achieve targeted cost reductions; our reliance on a limited number of suppliers for specified feedstock and services and our reliance on third-party transportation; the occurrence of unexpected manufacturing interruptions and outages, including those occurring as a result of labor disruptions and production hazards; exposure to physical risks associated with climate-related events or increased severity and frequency of severe weather events; availability of and/or higher-than-expected costs of raw material, energy, transportation, and/or logistics; the failure or an interruption, including cyber-attacks, of our information technology systems; our inability to complete future acquisitions or joint venture transactions or successfully integrate them into our business; risks associated with our international sales and operations, including economic, political or regulatory changes; our indebtedness and debt service obligations; weak industry conditions affecting our ability to comply with the financial maintenance covenants in our senior credit facility; adverse conditions in the credit and capital markets, limiting or preventing our ability to borrow or raise capital; the effects of any declines in global equity markets on asset values and any declines in interest rates or other significant assumptions used to value the liabilities in, and funding of, our pension plans; our long-range plan assumptions not being realized, causing a non-cash impairment charge of long-lived assets; Legal, Environmental and Regulatory Risks changes in, or failure to comply with, legislation or government regulations or policies, including changes regarding our ability to manufacture or use certain products and changes within the international markets in which we operate; new regulations or public policy changes regarding the transportation of hazardous chemicals and the security of chemical manufacturing facilities; unexpected outcomes from legal or regulatory claims and proceedings; costs and other expenditures in excess of those projected for environmental investigation and remediation or other legal proceedings; various risks associated with our Lake City U.S. Army Ammunition Plant contract and performance under other governmental contracts; and failure to effectively manage environmental, social and governance (ESG) issues and related regulations, including climate change and sustainability. All of our forward-looking statements should be considered in light of these factors. In addition, other risks and uncertainties not presently known to us or that we consider immaterial could affect the accuracy of our forward-looking statements. SOURCE Olin Corporation'Very much in a free fall': Doctors sound the alarm as drop-in medical clinics in B.C. disappear

Visitors bureau lists 2025 photo contestsThe Pennsylvania Great Outdoors Visitors Bureau has announced its lineup of photocontests for 2025. The four quarterly themes are Winter Wonders, Big Fish, Take aHike, and Scenic Views.The Winter Wonders photo contest runs from January through March. The annual BigFish Photo Contest is from April through June. The Take a Hike Photo Contest is Julythrough September. Finally, October through December will be the Scenic Views PhotoContest.Finalists’ photos for each contest period will be posted online with the four entriesreceiving the most votes winning the following cash prizes: 1st Place $100, 2nd Place$75, 3rd Place $50, and 4th Place $25 for Winter Wonders, Take a Hike, and ScenicViews contests. The Big Fish Photo Contest has monthly winners of prize packs fromPAGO members and two randomly selected grand prize winners.To enter complete the entry form and upload your photos at VisitPAGO.com/contest . Theonly requirements are that the photo meet the photo contest theme and must be taken inCameron, Elk, or Forest Counties.Oswego County Tourism lists fishing reportFishing in Oswego County, New York, has really heated up, despite droppingtemperatures. Weekly report highlights for the Salmon River are the best spots are theslower deeper pools and on the Oswego River are as the water drops, fishing will pickback up on the wall.The water has finally receded and there are steelhead spread throughout the SalmonRiver. The best spots are the slower deeper pools such as the Schoolhouse, Wire, Trestle,Pineville, Ace, Sportsman, Papermill, 81 and Town Pools.Christmas music featured on ETOA unique selection of Christmas music is featured on the Sunday, Dec. 29 edition of“Experience The Outdoors,” winner of the Pennsylvania Outdoor Writers Associationand Mason-Dixon Outdoor Writers Association awards for best outdoors radio program.Air times are: 7-7:30 a.m., AM 1410 WLSH; 8-8:30 a.m., Sunny 1100 WGPA; 9-9:30a.m., Magic 105.5-FM.; and downloaded on wmgh.com.Banquets Sauerkraut Supper , Saturday, Jan. 18, Friedensburg Fish and Game, 169 StoneMountain Road, Pine Grove; call 570-617-0492 for information.Hunts Mentored Youth Hunt : Saturday, Jan. 18, Stein’s Hollow Beagle Club, 259 East DeerView Drive, Auburn; Registration is 6-8 p.m., January 17, 6:30-8 a.m. the morning of theevent. For additional information call 484-955-1530, 570-294-5614 or visit Stein’sHollow Beagle Club on Facebook. Squirrel Hunt: Saturday, Feb. 1, Friedensburg Fish and Game, 169 Stone MountainRoad, Pine Grove; call 570-617-0492 for information.Shows Early Bird Sports Expo : Thursday-Sunday, Jan. 23-26, Bloomsburg Fairgrounds,Bloomsburg; for information and tickets, call 570-594-0252 orvisit www.earlybirdsportsexpo.com . Hours: Thursday, 3-8 p.m.; Friday, 10 a.m. to 8p.m.; Saturday, 10 a.m. to 8 p.m.; Sunday, 10 a.m. to 4 p.m. Philadelphia Boat Show: Friday-Sunday, Jan. 24-26, Greater Philadelphia Expo Centerat Oaks, 100 Station Ave., Oaks; for information go to www.phillyboatshow.com . Hours:Friday and Saturday, 10 a.m. to 6 p.m.; Sunday, 10 a.m.-2 p.m. Lancaster Muzzle Loading Rifle Association Gun Show: Friday and Saturday, Jan. 25and 26, Solanco Fairgrounds, 184 South Lime St., Quarryville; Hours: Saturday, 8 a.m. to4 p.m.; Sunday, 8 a.m. to 2 p.m. For information call 717-368-4653.This week’s events Wednesday: New Year’s Day Trout Event, 10 a.m. stocking, Little Schuylkill River,north of Tamaqua, oil tanks off Route 309; for information go to Schuylkill Headwaterspage on Facebook. Thursday: Trap, 5-6 p.m., youth; 6-9 p.m., adult, Orwigsburg Gun Club, Gun ClubRoad, off Route 443 East, Orwigsburg; email grsmmyminch@gmail.com for information. Saturday: West Penn Archery Club Saturday Night League , shoots are held at theclub, 147 Archery Club Road, New Ringgold. — Compiled by Doyle DietzSee what Nigerian governor did for resident sentenced to death for stealing fowlElon Musk, Vivek Ramaswamy start ‘brainstorming’ with Congress to cut government spending

Thomas Sorber collected 22 points, 12 rebounds and four blocks to pace Georgetown to an 83-53 win against shorthanded Coppin State on Saturday afternoon in Washington, D.C. The Hoyas pulled away from the Eagles with a 21-2 run early in the second half. Georgetown held Coppin State to 22 percent shooting in the second half and 18 percent from behind the arc. Georgetown (11-2) is off to its best start since the 2011-12 season. Drew Fielder recorded 20 points and 13 rebounds while Malik Mack had 15 points and 11 assists for the Hoyas. Georgetown played without its leading scorer Jayden Epps, who missed the game with a lower-body injury. Toby Nnadozie scored 22 points and Julius Ellerbe III added 12 to go along with six steals for the Eagles (1-13). The Hoyas' decisive second-half run started with Caleb Williams' steal that led to a Fielder lay up as Georgetown took 49-37 lead. Moments later, Fielder's turnaround in the lane put the Hoyas up 56-37. Sorber's jam with 6:36 left gave Georgetown a 67-41 advantage. The pesky Eagles rattled off a 7-0 run but got no closer than 19 points the rest of the game. The Eagles played without three of their top four scorers but forced 14 Georgetown turnovers in the first half and hit 5-of-8 3-pointers. Ellerbe corralled a loose ball near half court and distributed it to Nnadozie who converted a contested layup to pull CSU within 12-11. But the Hoyas held a 24-10 rebounding edge in the first half as Sorber and Fielder were a force inside the paint. The Hoyas created separation as Sorber worked the high-low game with a catch in the lane and a left finger roll for a 25-15 Hoyas' lead with 8:40 left in the first half. Zahree Harrison's 3-pointer kept the dogged visitors close and capped a 5-0 run that cut the Georgetown lead to 25-20. Nnadozie closed the first half with a 3-pointer and the Hoyas held a 37-30 lead. --Field Level Media

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TAMPA, Fla. (AP) — Bucky Irving isn’t choosy. The rookie running back relishes any opportunity he gets to contribute to the success of the Tampa Bay Buccaneers, who have rebounded from a tough stretch to climb back into a tie for first place in the NFC South. Irving leads NFL rookies in rushing with 732 yards, averaging 5.5 yards per carry while sharing the workload with starter Rachaad White and third-stringer Sean Tucker, who have combined to ease some of the burden on quarterback Baker Mayfield. A fourth-round draft pick out of Oregon, Irving is coming off rushing for a season-best 152 yards and a touchdown in last week’s 26-23 overtime win over the Carolina Panthers. He had another 33 yards receiving, giving him a rookie-leading 1,017 total yards from scrimmage through 12 games. The Bucs (6-6) on Sunday host the Las Vegas Raiders (2-10), who have an outstanding newcomer of their own with Brock Bowers on the verge of breaking the league's record for catches by a rookie tight end. Bowers leads all players, regardless of position, with 84 receptions. He's fourth with 884 yards receiving and second behind Irving among rookies with 895 total yards from scrimmage. “I don’t really like taking all the credit. It’s those guys up front,” Irving said, deferring to Tampa Bay’s improved offensive line. “I think I have to do something special for those guys for Christmas because they’re getting the job done.” The Bucs are eighth in the NFL in rushing at 137.2 yards per game. They’ve gained 100-plus yards on the ground in nine of 12 games after only doing it nine times in 34 games over the past two seasons. Irving, whose ability to make defenders miss and accelerate in the open field, has provided a spark to an offense that sputtered without injured wide receivers Mike Evans and Chris Godwin during a four-game losing streak. It doesn’t seem to bother the rookie that he still sits behind White on the depth chart. The starter had a 38-yard run in overtime to set up the winning field goal last week. Coach Todd Bowles continues to stress that the Bucs, tied with Atlanta for the NFC South lead, need both Irving and White to be successful. “In our room, all our success is one,” said Irving, who in the past two weeks became the first rookie since Miles Sanders in 2019 to string together consecutive games with 150-plus yards from scrimmage. “If I’m having success,’’ Irving added, “everybody in the room is having success.” Tampa Bay’s porous secondary figures to be tested by Bowers, the first tight end to lead the league in catches after Week 13 since Todd Christenson in 1986. The first-round draft pick out of Georgia needs three receptions to break Sam LaPorta’s season record (86 in 2023) for catches by a tight end. He’s 116 yards away from joining Mike Ditka (1,076 in 1961) and Kyle Pitts (1,026 in 2021) as the only rookie tight ends to finish with 1,000-plus yards receiving. “I thought he was one of the best tight ends coming out in a long time – not just this draft, but in a long time,” Bowles said. “He’s living up to expectations. He can play wideout, he can play tight end, he can do some fullback, he can run jet sweeps,” the Bucs coach added. “They do a lot of things with him and he’s a very talented guy.” The last time the Raiders went against Mayfield was two seasons ago when he came off a plane to play for the Los Angeles Rams. Despite having minimal time with the playbook and just one brief practice, Mayfield rallied the Rams to a 17-16 victory on a 23-yard touchdown pass with 10 seconds left. Raiders coach Antonio Pierce was the team’s linebackers coach at the time. “He plays the game kind of like Brett Favre, who I played against in (the) league,” Pierce said. “He’s very fiery. He’ll do whatever it takes to make a play. The play’s never dead with him. You’ve got to keep your eyes on him and then stay in coverage, so that’ll be a challenge.” Raiders quarterback Aidan O’Connell didn’t look as though he had missed nearly six weeks because of a broken thumb when he almost led Las Vegas to a victory at Kansas City last week. He completed 23 of 35 passes for 340 yards and two touchdowns in the Raiders’ 19-17 loss to the Chiefs. But O’Connell had a hard time looking at the positives given how close the Raiders came to beating the two-time defending Super Bowl champions. “Definitely some good plays, but it just stinks more than anything,” O’Connell said. “It was just a really hard loss. Even sometimes when you have a game right after, it’s easier to move on. But we had a longer week this week and so kind of really got to sit in it and it’s no fun.” AP Sports Writer Mark Anderson in Las Vegas contributed to this report. NFL: https://apnews.com/hub/nfl

NORTH CHARLESTON, S.C. (AP) — Daylen Berry scored 27 points as Charleston Southern beat Columbia International 95-89 on Saturday. Berry had 10 rebounds for the Buccaneers (4-11). RJ Johnson scored 25 points while shooting 7 for 19 (0 for 6 from 3-point range) and 11 of 13 from the free-throw line and added seven assists. Keenan Wilkins went 4 of 12 from the field (3 for 8 from 3-point range) to finish with 11 points, while adding six rebounds. JJ Vaughan finished with 24 points for the Rams. Columbia International also got 22 points from Christian Howard. Brandon Hunt also had 13 points and 11 rebounds. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .