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(Azacitidine + cedazuridine) is under clinical development by Taiho Oncology and currently in Phase III for Refractory Anemia With Excess Blasts. According to GlobalData, Phase III drugs for Refractory Anemia With Excess Blasts have a 67% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. (Azacitidine + cedazuridine) overview ASTX-030, a fixed dose combination of azacitidine and cedazuridine is under development for the treatment of myelodysplastic syndromes (MDS), chronic myelocytic leukemia (CML), refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML). It is administered by oral route. It acts by targeting DNA (cytosine 5) methyltransferase 1 and cytosine deaminase (CDA). The drug candidate is being developed based on Pyramid technology. Taiho Oncology overview Taiho Oncology, a subsidiary of Taiho Pharmaceutical Co Ltd, is a provider of cancer treatments and solutions. The company manufactures and markets cancer anti-metabolites as well as targeted small molecule inhibitors. Its products portfolio includes oral drugs for the treatment of gastric cancer, colorectal cancer and a variety of solid tumours. Taiho Oncology’s pipeline products includes anti metabolic agents and selectively targeted agents. The company’s LONSURF is an anti-cancer drug for the treatment of metastatic colorectal cancer. Taiho Oncology is headquartered in Princeton, New Jersey, the US. For a complete picture of (Azacitidine + cedazuridine)’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .nextbet live casino

The Bitcoin rally sparked by US President-elect Donald Trump ’s election victory in early November is stalling as 2024 draws to a close. The digital asset wavered at $93,678 as of 7:53 a.m. on Monday in Singapore, about $15,000 below the record high set in mid-December. Smaller tokens like Ether and meme-crowd favorite Dogecoin also struggled for traction. Trump’s preference for crypto friendly regulations and support for the idea of a national Bitcoin reserve lifted digital assets. But scaled back expectations for interest-rate cuts by the Federal Reserve have cooled the speculative frenzy. Also read: Montenegro to extradite crypto entrepreneur Do Kwon to US More clarity on the US crypto regime is likely to emerge after Trump assumes power on Jan. 20. The Republican’s stance contrasts with President Joe Biden’s administration, which cracked down on the scandal-prone sector. Chris Weston, head of research at Pepperstone Group, said “the momentum has come out of the post-election move” in Bitcoin, partly due to outflows from exchange-traded funds for the token. Meanwhile, software maker turned Bitcoin accumulator MicroStrategy Inc. has been on a buying spree in the past few weeks. Traders are waiting to see if the company — which owns more than $40 billion of the digital asset — will continue a pattern of announcing Bitcoin purchases on Mondays. Also read: Who is Satoshi Nakamoto, the creator of Bitcoin? The original cryptocurrency has climbed roughly 120% this year, outstripping traditional investments such as global stocks and gold. Bitcoin also more than doubled in 2023 in a comeback from a deep bear market.Xavier Bell scores 29 to lead Wichita State over Friends University 87-72

India News Today Live Updates on December 30, 2024 : Jammu and Kashmir Weather Forecast and AQI Today on December 30, 2024: Today's temperature is -27.27 °C., Here's the latest weather forecast

The Central High School football team will face off against Edison of Huntington Beach on Saturday, Dec. 14, for the Division 1-A CIF State championship at Saddleback College. It’ll be the Grizzlies’ second state championship game in five seasons. Related Story: Grizzlies’ Impressive Season and Program Success Central is 12-2 ranked No. 20 in the state. The Grizzlies captured their fourth Central Section Division 1-AA football championship (2017, 2018, 2019) by beating Clovis East, 33-24, on Nov. 22. The program’s successes have been under the leadership of head coach Kyle Biggs. Since taking over the program in 2016 the Grizzlies have appeared in six section title games and won the 2019 state championship in Division 1-AA, 34-19, over Sierra Canyon to finish with a 15-0 record. That 2019 state title team included wide receiver Xavier Worthy, who became a first-round NFL draft pick and is in his rookie season with the two-time Super Bowl champion Kansas City Chiefs. Another wideout on that Central team, Jeremiah Hunter, has 33 receptions for the University of Washington this season. In 11 seasons, Biggs has a 107-26 career record — two years at Fowler and nine at Central. In the North Regional Final playoff game on Saturday against St. Ignatius College Prep of San Francisco, the night belonged to Brandon Smith as he scored five touchdowns. He rushed for three touchdowns (200 rushing yards), caught a scoring pass, and returned a fumble for a score — accounting for all of Central’s TDs in a 33-23 victory. The victory propelled Central into the state championship game. Related Story: Standouts Dippel, Smith Lead the Charge The standouts for the Grizzlies are Smith and sophomore quarterback Jelani Dippel. Dippel has passed for 3,230 yards and 39 touchdowns while rushing 49 times for 378 yards with three touchdowns. Smith powers the ground attack and also anchors the defense. He has rushed for 1,800 yards and 25 touchdowns and made 27 receptions for 260 yards and two touchdowns. On the defensive side, he has 167 tackles, two interceptions, and 3.5 sacks. Related Story: Edison’s Journey to the Championship Edison, the Southern Section D3 champions, beat Granite Hills of El Cajon, 34-28, on Saturday in the CIF State Southern California Regional Division 1-A final playoff game to reach the CIF state finals for the first time. The Chargers are 11-4 and ranked No. 18 in the state. The Chargers appeared in the state playoffs in 2012 and 2016 but lost both times. In its season opener, Edison lost to Clovis West, 29-28.

Unisys Corporation Announcement: If You Have Suffered Losses in Unisys Corporation (NYSE: UIS), You Are Encouraged to Contact The Rosen Law Firm About Your RightsFresh videos show heavy clashed between Pakistan and Afghan Taliban forces in Kurram and North Waziristan areas at the Pakistan-Afghanistan international border. New Delhi: Fresh clashes have erupted between Afghan Taliban and Pakistani forces at the international border leading to reported casualties on Taliban side. Videos of the heavy clashed between the two sides have emerged on social media. The new videos show Pakistan forces launching heavy rocket attacks against Taliban posts on the border. Th videos further shows the Pakistani army hitting Taliban border posts with Anti-Tank Guided Missile (ATGM) and artillery fire at multiple posts subsequently destroying them. There are reports of heavy casualties inflected on Taliban side. Clashes in Kurram and North Waziristan The clashed reportedly took place at Kurram and North Waziristan on the Pakistan-Afghanistan International border. The Pakistani army has claimed that it has killed at least 20 Taliban fighters and destroyed six of their posts. The Pakistan army also claimed to have captured at least 40 Taliban fighters. The clashed video also shows huge plume of smoke billowing from the Taliban posts after they were hit by Pakistan forces. Click for more latest World news . Also get top headlines and latest news from India and around the world at News9. Nakshab Khan has been a journalist since 2007 and worked with prominent media houses like News18, IANS, Zee Media UNI TV, and Times Now. He joined News9 as News Editor. He has vast experience of covering politics, international affairs, crime in various industry brands. Nakshab likes to talk about world issues and has written on various topic related to West Asian affairs. In his career spanning nearly 17 years, he has always delivered error free and facts based stories and had an unblemished working style. You can reach out to him at nakshab.khan@tv9.comNew York, NY November 22, 2024 --( PR.com )-- BDA Partners is pleased to announce that its client, Nippon Sangyo Suishin Kiko, has reached an agreement on the sale of its stake in Japan Energy Components to Obara Group, a Japan-based machine industry company comprised of the parent and a global network of 27 subsidiaries, through which it manufactures and sells its products worldwide. BDA was the exclusive financial advisor to NSSK on the transaction. JEC, headquartered in Ishioka City, Ibaraki Prefecture, Japan, manufactures electric power transmission components and spiral products for power companies and renewable energy operators. Additionally, JEC manufactures quick-charging cable connectors for electric vehicles. Going forward, Obara plans to leverage JEC Group’s robust business foundation, while using its global management resources to drive further growth. Suguru Sasaki, Director, BDA Partners, said: “We’re pleased to have helped JEC find a new partner, and confident that JEC will thrive as part of Obara Group. We’re proud to have advised NSSK, a leading Japanese private equity firm, which was awarded the “Firm of the Year in Japan” by Private Equity International in five of the last seven years. This is our second transaction for NSSK, having previously advised on the sale of ORF/IIT to Hokkaido LogiService in early 2024.” The deal team was Suguru Sasaki, Drake Mitsukawa, Akira Komiya, Toshiaki Yokohara and Atsushi Masuda. About NSSK Nippon Sangyo Suishin Kiko Group (NSSK) is an investment management business with a focus on Japan. Its mission is to build a leading alternative asset investment business by investing in attractive Japanese companies in partnership with management, contributing to the Environment, Society and Governance of Japan and beyond. NSSK’s investment strategy is to seek to generate superior outcomes by applying global investment discipline, operating expertise and human capital to Japanese companies originating from our proprietary and differentiated sourcing network. NSSK was named “Firm of the Year in Japan” award by Private Equity International in 2017, 2018, 2020, 2022 and 2023. www.nsskjapan.com About Obara OBARA Group Inc is one of the largest Japanese suppliers of total welding solutions. OBARA is introducing resistance welding systems for the automotive industry and arc welding tools for the shipbuilding and construction industries. It was founded in 1955 and is headquartered in Yamato, Japan. www.obara-g.com About BDA Partners BDA Partners is the global investment banking advisor for Asia. We are a premium provider of Asia-related advice to sophisticated clients globally, with 25 years’ experience advising on cross-border M&A, capital raising, and financial restructuring. We provide global reach with our teams in New York and London, and true regional depth through our seven Asian offices in Mumbai, Singapore, Ho Chi Minh City, Hong Kong, Shanghai, Seoul and Tokyo. BDA has deep expertise in the Chemicals, Consumer & Retail, Health, Industrials, Services, Sustainability and Technology sectors. We work relentlessly to earn our clients’ trust by delivering insightful advice and outstanding outcomes. BDA Partners has strategic partnerships with William Blair, a premier global investment banking business, and with DBJ (Development Bank of Japan), a Japanese government-owned bank with US$150bn of assets. US securities transactions are performed by BDA Partners’ affiliate, BDA Advisors Inc, a broker-dealer registered with the Securities and Exchange Commission (SEC). BDA Advisors Inc is a member of the Financial Industry Regulatory Authority (FINRA) and SIPC. In the UK, BDA Partners is authorized and regulated by the Financial Conduct Authority (FCA). In Hong Kong, BDA Partners (HK) Ltd is licensed and regulated by the Securities & Futures Commission (SFC) to conduct Type 1 and Type 4 regulated activities to professional investors. www.bdapartners.com Contact Information: BDA Partners Euan Rellie 212-265-5300 Contact via Email www.bdapartners.com Read the full story here: https://www.pr.com/press-release/925940 Press Release Distributed by PR.com © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

WASHINGTON (AP) — President-elect Donald Trump's pick for intelligence chief, Tulsi Gabbard, faced fresh scrutiny Monday on Capitol Hill about her proximity to Russian-ally Syria amid the sudden collapse of that country's hardline Assad rule. Gabbard ignored shouted questions about her 2017 visit to war-torn Syria as she ducked into one of several private meetings with senators who are being asked to confirm Trump's unusual nominees . But the Democrat-turned-Republican Army National Reserve lieutenant colonel delivered a statement in which she reiterated her support for Trump's America First approach to national security and a more limited U.S. military footprint overseas. “I want to address the issue that’s in the headlines right now: I stand in full support and wholeheartedly agree with the statements that President Trump has made over these last few days with regards to the developments in Syria,” Gabbard said exiting a Senate meeting. The incoming president’s Cabinet and top administrative choices are dividing his Republican allies and drawing concern , if not full opposition, from Democrats and others. Not just Gabbard, but other Trump nominees including Pentagon pick Pete Hegseth, were back at the Capitol ahead of what is expected to be volatile confirmation hearings next year. The incoming president is working to put his team in place for an ambitious agenda of mass immigrant deportations, firing federal workers and rollbacks of U.S. support for Ukraine and NATO allies. “We’re going to sit down and visit, that’s what this is all about,” said Sen. Mike Rounds, R-S.D., as he welcomed Gabbard into his office. The president-elect announced other appointments Monday, including his lawyer Harmeet Dhillon for assistant attorney general for civil rights at the Justice Department and Mark Paoletta as the returning general counsel of the Office of Management and Budget. Meanwhile, Defense Secretary pick Hegseth appeared to be picking up support from once-skeptical senators, the former Army National Guard major denying sexual misconduct allegations and pledging not to drink alcohol if he is confirmed. The president-elect's choice to lead the FBI, Kash Patel , who has written extensively about locking up Trump's foes and proposed dismantling the Federal Bureau of Investigation, launched his first visits with senators Monday. “I expect our Republican Senate is going to confirm all of President Trump’s nominees,” said Sen. Tom Cotton, R-Ark., on social media. Despite widespread concern about the nominees' qualifications and demeanors for the jobs that are among the highest positions in the U.S. government, Trump's team is portraying the criticism against them as nothing more than political smears and innuendo. Showing that concern, nearly 100 former senior U.S. diplomats and intelligence and national security officials have urged Senate leaders to schedule closed-door hearings to allow for a full review of the government’s files on Gabbard. Trump's allies have described the criticisms of Hegseth in particular as similar to those lodged against Brett Kavanaugh, the former president's Supreme Court nominee who denied a sexual assault allegation and went on to be confirmed during Trump's first term in office. Said Sen. Lindsey Graham, R-S.C., about Hegseth: “Anonymous accusations are trying to destroy reputations again. We saw this with Kavanaugh. I won’t stand for it.” One widely watched Republican, Sen. Joni Ernst of Iowa, herself a former Army National Guard lieutenant colonel and sexual assault survivor who had been criticized by Trump allies for her cool reception to Hegseth, appeared more open to him after their follow-up meeting Monday. “I appreciate Pete Hegseth’s responsiveness and respect for the process,” Ernst said in a statement. Ernst said that following “encouraging conversations,” he had committed to selecting a senior official who will "prioritize and strengthen my work to prevent sexual assault within the ranks. As I support Pete through this process, I look forward to a fair hearing based on truth, not anonymous sources.” Ernst also had praise for Patel — “He shares my passion for shaking up federal agencies" — and for Gabbard. Once a rising Democratic star, Gabbard, who represented Hawaii in Congress, arrived a decade ago in Washington, her surfboard in tow, a new generation of potential leaders. She ran unsuccessfully for president in 2020. But Gabbard abruptly left the party and briefly became an independent before joining with Trump's 2024 campaign as one of his enthusiasts, in large part over his disdain for U.S. involvement overseas and opposition to helping Ukraine battle Russia. Her visit to Syria to meet with then-President Bashar Assad around the time of Trump's first inauguration during the country's bloody civil war stunned her former colleagues and the Washington national security establishment. The U.S. had severed diplomatic relations with Syria. Her visit was seen by some as legitimizing a brutal leader who was accused of war crimes. Gabbard has defended the trip, saying it's important to open dialogue, but critics hear in her commentary echoes of Russia-fueled talking points. Assad fled to Moscow over the weekend after Islamist rebels overtook Syria in a surprise attack, ending his family's five decades of rule. She said her own views have been shaped by “my multiple deployments and seeing firsthand the cost of war and the threat of Islamist terrorism.” Gabbard said, “It's one of the many reasons why I appreciate President Trump’s leadership and his election, where he is fully committed, as he has said over and over, to bring about an end to wars.” Last week, the nearly 100 former officials, who served in both Democratic and Republican administrations, said in the letter to Senate leaders they were “alarmed” by the choice of Gabbard to oversee all 18 U.S. intelligence agencies. They said her past actions “call into question her ability to deliver unbiased intelligence briefings to the President, Congress, and to the entire national security apparatus.” The Office of the Director of National Intelligence was created after the Sept. 11, 2001, attacks to coordinate the nation’s intelligence agencies and act as the president’s main intelligence adviser. Associated Press writer Stephen Groves contributed to this report.


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